HYPOXIA AND THE PHENOMENON OF IMMUNE EXCLUSION

Hypoxia and the phenomenon of immune exclusion

Abstract Over the last few years, cancer immunotherapy experienced tremendous developments and it is nowadays considered a promising strategy against many types of cancer.However, the exclusion of lymphocytes from the tumor nest is a common phenomenon that limits the efficiency of immunotherapy in solid tumors.Despite several mechanisms proposed du

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A Phase 2a Randomized, Double-Blind, Dose-Optimizing Study to Evaluate the Immunogenicity and Safety of a Bivalent DNA Vaccine for Hemorrhagic Fever with Renal Syndrome Delivered by Intramuscular Electroporation

Hantaan virus (HTNV) and Puumala virus (PUUV) are pathogenic hantaviruses found in Asia and Europe, respectively.DNA vaccines targeting the Chamomile envelope glycoproteins of these viruses have been constructed and found to elicit neutralizing antibodies when delivered to humans by various technologies including intramuscular electroporation.Here,

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R7 photoreceptor axon targeting depends on the relative levels of lost and found expression in R7 and its synaptic partners

As neural circuits form, growing processes select the correct synaptic partners through interactions between cell surface proteins.The presence of such proteins on two neuronal processes may lead to either adhesion or repulsion; however, the consequences of mismatched expression have rarely been explored.Here, we show that the Drosophila Chamomile

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Digital Representation of Color Stitches in Craft Software

This paper studies problems related to the development of craft software.It proposes an approach to developing an application for digital representation of color stitches in cross stitch pattern and crochet software.A database containing information about the Bandage Bags most popular embroidery floss brands in Bulgaria has been built.The software

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